Aqueous Non-Preserved Formulation BUD refrigerated duration?

Aqueous Non-Preserved Formulation BUD refrigerated duration?

• A. 14 days
• B. 35 days
• C. 90 days
• D. 180 days

Answer: (A)

Aqueous formulations that do not contain an antimicrobial preservative have the shortest beyond-use dating because they’re more vulnerable to microbial growth. When a preservative isn’t present, keeping the product in the refrigerator slows growth but does not prevent it, so the BUD is limited to 14 days. If a preservative were used, the BUD could be longer (around 35 days) under refrigeration. Non-aqueous formulations, by contrast, can have much longer BUDs. So for an aqueous, non-preserved formulation stored refrigerated, the appropriate BUD is 14 days.

Aqueous formulations that do not contain an antimicrobial preservative have the shortest beyond-use dating because they’re more vulnerable to microbial growth. When a preservative isn’t present, keeping the product in the refrigerator slows growth but does not prevent it, so the BUD is limited to 14 days. If a preservative were used, the BUD could be longer (around 35 days) under refrigeration. Non-aqueous formulations, by contrast, can have much longer BUDs. So for an aqueous, non-preserved formulation stored refrigerated, the appropriate BUD is 14 days.